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Functional HIF-1 corresponding elements were found in the promoter sequence of the human BNP gene, proving that HIF-1 can induce the activation of the BNP promoter, the transcription of BNP mRNA, and the synthesis and secretion of BNP under hypoxic conditions [90]

RadwanMHAlaidaroosBAJastaniahSDAbu El-NagaMNEl-GoharyE-GEBarakatEMet alEvaluation of antibacterial activity induced by Staphylococcus aureus and Ent A in the hemolymph of Spodoptera littoralis

The pathogenesis of DN involves complex interactions among metabolic dysregulation, oxidative stress, inflammatory responses, and fibrotic signaling pathways (Figure 1)

Samples from different conditions are combined early in processing, with relative protein abundance determined by heavy-to-light peptide signal ratios (Peters-Hall et al., 2015)